Complete Nucleotide Sequence of an IncI2 Plasmid Coharboring blaCTX-M-55 and mcr-1.

نویسندگان

  • Jian Sun
  • Xing-Ping Li
  • Run-Shi Yang
  • Liang-Xing Fang
  • Wei Huo
  • Shu-Min Li
  • Peng Jiang
  • Xiao-Ping Liao
  • Ya-Hong Liu
چکیده

We report the complete nucleotide sequence of a plasmid, pA31-12, carrying blaCTX-M-55 and mcr-1 from a chicken Escherichia coli isolate. pA31-12 has an IncI2 replicon that displays extensive sequence similarity with pHN1122-1-borne blaCTX-M-55 and pHNSHP45-borne mcr-1 Insertion sequences ISEcp1 and ISApl1 are responsible for the mobilization of blaCTX-M-55 and mcr-1, respectively. The colocalization of mcr-1 with an extended-spectrum β-lactamase gene on a conjugative plasmid may accelerate the dissemination of both genes by coselection.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 60 8  شماره 

صفحات  -

تاریخ انتشار 2016